姓名:雷东升

						雷东升,男,博士,兰州大学物理科学与技术学院教授,硕士生导师。于2006年、2009年和2014年分别获西安交通大学物理学学士、硕士和博士学位。2014年至2019年间在美国劳伦斯伯克利国家实验室工作。2019年6月至今就职于兰州大学物理科学与技术学院、电镜中心。主要利用冷冻电子断层扫描和分子动力学模拟方法,研究生物大分子的柔性结构和功能。在Nature Communications、Nature Chemical Biology和BBA-Molecular and Cell Biology of Lipids等SCI刊物上发表论文16篇。
					

						1、	发展冷冻电子断层扫描技术(cryo-electron tomography);
2、	分子动力学模拟方法及其应用;
3、	柔性生物大分子(如脂蛋白、抗体和DNA折纸等)的结构和功能。
					
						1.	Dongsheng Lei, Yadong Yu, Yu-Lin Kuang, Jianfang Liu, Ronald M. Krauss, Gang Ren. Single-Molecule 3D Imaging of Human Plasma Intermediate-Density Lipoproteins Reveals a Polyhedral Structure. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2019, 1864(3):260-270

2.	Dongsheng Lei, Jianfang Liu, Hongbin Liu, Thomas E. Cleveland IV, John P. Marino, Ming Lei, Gang Ren. Single-Molecule 3D Images of “Hole-Hole” IgG1 Homodimers by Individual-Particle Electron Tomography. Scientific Reports, 2019, 9:8864

3.	Valentina Masciotti, Luca Piantanida, Denys Naumenko, Heinz Amenitsch, Mattia Fanetti, Matjaž Valant, Dongsheng Lei, Gang Ren, Marco Lazzarino. A DNA origami plasmonic sensor with environment-independent read-out. Nano Research, 2019, 12(11): 2900–2907

4.	Hao Wu, Xiaobo Zhai, Dongsheng Lei, Jianfang Liu, Yadong Yu, Rongfang Bie, Gang Ren. An Algorithm for Enhancing the Image Contrast of Electron Tomography. Scientific Reports, 2018, 8:16711

5.	Dongsheng Lei, Alex Marras, Jianfang Liu, Chaomin Huang, Lifeng Zhou, Shawn Zheng, Michael Braunfeld, David Agard, Carlos Castro, Hai-Jun Su, Gang Ren. Three-dimensional structural dynamics of DNA origami Bennett linkages using individual-particle electron tomography. Nature Communications, 2018, 9:592

6.	Meng Zhang, Dongsheng Lei, Bo Peng, Mickey Yang, M Art Charles, Kerry-Anne Rye, Ronald M Krauss, Douglas G Johns, Gang Ren. Assessing the mechanisms of cholesteryl ester transfer protein inhibitors. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2017, 1862(12): 1606-1617

7.	Hui-Min Zhang, Charlene Li, Ming Lei, Victor Lundin, Ho Young Lee, Milady Ninonuevo, Kevin Lin, Guanghui Han, Wendy Sandoval, Dongsheng Lei, Gang Ren, Jennifer Zhang, Hongbin Liu. Structural and Functional Characterization of a Hole-Hole Homodimer Variant in a “Knob-Into-Hole” Bispecific Antibody. Analytical Chemistry, 2017, 89(24): 13494-13501

8.	Dongsheng Lei, Matthew Rames, Xing Zhang, Lei Zhang, Shengli Zhang, Gang Ren. Insights into the tunnel mechanism of cholesteryl ester transfer protein using all-atom molecular dynamics simulations. The Journal of Biological Chemistry, 2016, 291(27):14034-14044

9.	Lei Zhang, Dongsheng Lei, Jessica Smith, Meng Zhang, Huimin Tong, Xing Zhang, Zhuoyang Lu, Jiankang Liu, Paul Alivisatos, Gang Ren. Three-dimensional structural dynamics and fluctuations of DNA-nanogold conjugates by individual-particle electron tomography. Nature Communications, 2016, 7: 11083

10.	Yadong Yu, Yu-Lin Kuang, Dongsheng Lei, Xiaobo Zhai, Meng Zhang, Ronald M. Krauss, Gang Ren. Polyhedral 3D Structure of Human Plasma Very-Low-Density Lipoproteins by Individual Particle Cryo-Electron Tomography. Journal of Lipid Research, 2016, 57(10):1879-1888

11.	Xiangyu Deng, Xiangjing Qin, Lei Chen, Qian Jia, Yonghui Zhang, Zhiyong Zhang, Dongsheng Lei, Gang Ren, Zhihong Zhou, Zhong Wang, Qing Li, Wei Xie. Large Conformational Changes of Insertion 3 in Human Glycyl-tRNA synthetase (hGlyRS) during Catalysis. The Journal of Biological Chemistry, 2016, 291(11):5740-5752

12.	Xing Zhang, Dongsheng Lei, Lei Zhang, Matthew Rames, Shengli Zhang. A Model of Lipid-Free Apolipoprotein AI Revealed by Iterative Molecular Dynamics Simulation. PloS one, 2015, 10(3):e0120233

13.	Dongsheng Lei, Huimin Tong, Lei Zhang, Xing Zhang, Shengli Zhang, Gang Ren. Structure and Function of Cholesteryl Ester Transfer Protein in Transferring Cholesteryl Ester. Progress in Chemistry, 2014, 26(5):879-888

14.	Dongsheng Lei, Xing Zhang, Shengbo Jiang, Zhaodi Cai, Matthew J Rames, Lei Zhang, Gang Ren, Shengli Zhang. Structural features of cholesteryl ester transfer protein: A molecular dynamics simulation study. Proteins-Structure Function and Bioinformatics, 2013, 81(3): 415-425

15.	Lei Zhang, Feng Yan, Shengli Zhang, Dongsheng Lei, Arthur M. Charles, Giorgio Cavigiolio, Michael Oda, Ronald M. Krauss, Karl H. Weisgraber, Kerry-Anne Rye, Henry J Pownall, Xiayang Qiu, Gang Ren. Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein. Nature Chemical Biology, 2012, 8(4):342-349

16.	Lei Zhang, Shengli Zhang, Huimin Tong, Dongsheng Lei, Bambi Hu. Spontaneously periodic wave generation in coupled excitable media. Physical Review E, 2009, 79(5):056213
					
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